Biographical Sketch

Dr. Stone was born in Beech Grove, Indiana in 1967. He attended, Wabash College, a small private liberal arts college in Crawfordsville, Indiana, from where he graduated summa cum laude with a B.A. in chemistry. He then entered the Medical Scientist Training Program at the University of Michigan in Ann Arbor, Michigan. His doctoral thesis research was performed in the laboratory of Prof. Michael A. Marletta, one of the key scientists responsible for the discovery of nitric oxide generation by mammalian cells. There, Dr. Stone purified and characterized the sensor for nitric oxide, the soluble form of guanylate cyclase. Using spectral and rapid-kinetic techniques, Dr. Stone discovered that this heme-based sensor has an unusual heme environment, previously unknown in mammalian physiology, which allows the protein to be responsive to physiologic levels of nitric oxide, while not interacting with molecular oxygen. Dr. Stone graduated from the University of Michigan in 1997 with an M.D. and a Ph.D. in Biological Chemistry.

Dr. Stone then entered the Anatomic Pathology Residency Program at Brigham and Women’s Hospital and became a Clinical Fellow in Pathology at Harvard Medical School. Dr. Stone served as Chief Resident in Anatomic Pathology at BWH and completed both clinical fellowship training in Cardiovascular Pathology at BWH and also post-doctoral research on endothelial cell biology in the Vascular Research Division at BWH and at Children’s Hospital. Dr. Stone joined the staff at BWH as a Cardiovascular Pathologist, and became an Instructor in Pathology at Harvard Medical School.

In 2003, Dr. Stone accepted the position of Head of the Cardiovascular Pathology Service at Massachusetts General Hospital and became an Assistant Professor of Pathology at Harvard Medical School. Dr. Stone is currently an Associate Professor of Pathology at Harvard Medical School and directs an independent research laboratory studying basic mechanisms of cardiovascular disease. Dr. Stone directs both the Autopsy Service and the Cardiovascular Surgical Pathology Service at MGH. He also directs the Cardiovascular Histology Core Facility at MGH, which serves as a central core laboratory for NIH-funded multicenter trials relating to cardiovascular diseases.

James R. Stone, M.D., Ph.D.

Associate Professor of Pathology,
Harvard Medical School
Head of Cardiovascular Pathology Service, Massachusetts General Hospital

Massachusetts General Hospital
Simches Building, Rm 8236
185 Cambridge Street, CPZN
Boston, MA 02114

Phone: 617-726-8303
Fax: 617-726-2365
Email: jrstone@partners.org

Download the complete Stone Bibliography in PDF